MEDICATION -**How prepared

CONCENTRATION

Normal dosing

Normal range

Comments

Abciximab(Reopro) - RN

9mg/250cc

A. mcg/kg/MIN

B. mcg/MIN

A. AFTER intervention =0.125mcg/kg/MIN for 12 hours to a maximum of 10 mg/min

B. PRE INTERVENTION = 10 mcg/MIN

Loading dose = 0.25mg/kg bolus

Please note different doses PRE and POST intervention Monitor platelets at 2, 4 and 24 hours

Aminocaproic Acid(Amicar)- RN/P

10 grams/100cc

grams/HOUR

1.0-3.0 grams/HOUR

Loading dose 5 Grams over 1 hours

Amiodarone (Cordorone) - P

900 mg/500cc D5W

mg/MIN

1.0    mg/min over 6 HOURs = 33.3cc/hr THEN 0.5 mg/MIN = 16.6 cc/HOUR

Loading dose = 150mg/100cc D5W over 10 minutes

Aprotinin (Trasylol) - B

1,000,000KIU/100cc

2,000,000KIU/200cc

KIU/HOUR

Or mg/HOUR

250,000 KIU/HOUR = 35 mg/HOUR

OR 500,000 KIU/HOUR = 70 mg/HOUR

1.4mg=10,000KIU

Argatroban - P

250mg/250cc NaCl

mcg/kg/MIN

2-10 mcg/kg/MIN

See Argatroban protocol. Monitor dose in liver failure

Ativan see Lorazapam

 

 

 

 

Bumetanide (Bumex) - P

10mg/100cc

mg/HOUR

0.5-1.0 mg/HOUR

12 mg/day maximum

Cardene see Nicardipine

 

 

 

 

Cardizem see Diltiazem

 

 

 

 

Cisatricurium (Nimbex) - P

200mg / 100cc

mcg/kg/MIN

1-3 mcg/kg/MIN

Use twitch and BIS monitor

Cordarone see Amiodarone

 

 

 

 

Corlapam see Fenoldapam

 

 

 

 

Dexmedetomidine(Precedex) - P

400mcg/100cc NaCl

mcg/kg/HOUR

0.2-2.0 mcg/kg/HOUR

SEE SEDATION PROTOCOL

Diltiazem (Cardizem) - RN/P

125 mg/125cc:

Add 125 mg/25cc to 100cc bag = 125 mg in 125cc

mg/HOUR

5- 15 mg/HOUR

(5cc-15cc/HOUR)

Loading dose =

0.25mg/kg (first bolus)

0.35/mg/kg (second bolus)

Dobutamine (Dobutrex) - B

500 mg/250cc

mcg/kg/MIN

2.0-20 mcg/kg/MIN

Usual dose = 2.5-10mcg/kg/min

Drotrecogin (XIGRIS) - P

20 mg/100cc

mcg/kg/HOUR

CONSTANT RATE OF 24mcg/kg/HOUR

PLEASE NOTE: CONSTANT RATE = 24mcg/kg/HOUR X 96 hours. Dedicated line. Mark start date on MAR

Dopamine (Intropin) - B

400 mg/250cc

mcg/kg/MIN

3-20mcg/kg/MIN

Renal dosing = 1-5 mcg/kg/MIN

Doxapram - P

400mg/100cc

mg/MIN

1-3 mg/MIN

Start at 5 mg/min then reduce to 1-3mg/min

Epinephrine (Adrenaline) RN/P

4mg/250cc

mcg/MIN

1-4 mcg//MIN - vasopressor

For treatment of asthma: Range = 1-2 mcg/MIN

Epoprostenol (Flolan) - P

500,000 nanograms/100cc

Nanograms/kg/min

Start at 2 nanograms/kg/MIN

Increase by 2 nanograms/kg/min q 15 min until dose limiting symptoms (frequently jaw pain)

Eptifibatide (Integrilin) - RN

75 mg/100cc

200 mg/100cc

mcg/kg/MIN

2mcg/kg/MIN for all uses

For creatinine > 2 = 1 mcg/kg/MIN

Bolus = 180 mcg/kg

Maximum rate = 20 ml/hour

Esmolol (Brevibloc) - B

2500 mg/250cc

mcg/kg/MIN

50-200 mcg/kg/MIN

Loading Dose = 500 mcg/kg/min over 1 minute

Fenoldapam (Corlapam) - P

10 mg/250cc

mcg/kg/MIN

Renal perfusion = 0.03-0.05 mcg/kg/MIN

Hypertension: 0.03-1.6 mcg/kg/MIN

Fentanyl (Sublimaze) - P

2500 mcg/250cc

mcg/kg/HOUR

1-3 mcg/kg/HOUR

 

Flolan see epoprostenol

 

 

 

 

Furosemide (Lasix) P

100mg/100cc

mg/HOUR

5-10mg/HOUR

After 10 mg consider adding another diuretic

Heparin - B

25000 units/500cc

units/HOUR

400-2000 units/HOUR

(8cc-40cc/HOUR)

See heparin protocol

Insulin (Regular Humulin) P

50 units/100cc

units/HOUR

0.5 16 units/HOUR

(1cc-32 cc/HOUR)

 

See insulin protocol

Integrillin see Eptifibatide

 

 

 

 

Isoproteranol (Isuprel) - P

1mg/250cc

mcg/MIN

2-20 mcg/MIN

Bolus with 0.02-0.06 mg X 1

Kphosphorous drip - P

15mmol/250cc

30mmol/250cc

mmol/HOUR

Run at 50 cc/HOUR

Run over at least 4 hours.

30 mmol= 44.4meqKCL

Labetolol (Trandate/Normodyne) P

200 mg/250cc

400 mg/250cc

mg/MIN

0.5-3 mg/MIN

20 mg over 2 min

Lasix see furosemide

 

 

 

 

Lidocaine (Xylocaine) - B

2 grams/500cc

mg/MIN

1-4 mg/MIN

(15cc-60cc/HOUR)

 

Lorazapam (Ativan) - P

50 mg/100cc

mg/HOUR

0.5-5mg/HOUR

(1cc-10cc/HOUR)

 

Magnesium Sulfate - B

1 Grams/100cc

4 Grams/100cc

grams/HOUR

1 - 2 grams over 1 HOUR

electrolyte protocol suggested

Midazolam (Versed) - P

50 mg/100cc

mg/HOUR

0.5-6 mg/HOUR

(1cc-12cc/HOUR)

Limited to 48 hour or less of infusion

Milronone (Primacor) - B

40 mg/200 cc

mcg/kg/MIN

0.375-0.75 mcg/kg/MIN

Loading dose = 50 mcg/kg over 10 min

Nesiritide (Natrecor) P

1.5 mg/250cc

mcg/kg/MIN

0.01-0.03 mcg/kg/MIN

Bolus dose = 2.0 mcg/kg

Nicardipine(Cardene) P

50 mg/100cc

mg/HOUR

5-15 mg/HOUR

 

Nitroglycerine (Tridil) - B

50 mg/250cc

mcg/MIN

10 -400 mcg/MIN

(3cc-72cc/HOUR)

 

Nitroprusside(Nipride)-RN

50 mg/250cc

mcg/kg/MIN

0.5-10mcg/kg/MIN

Usual dose = 3mcg/kg/min

Watch for cyanide toxicity

Norepinephrine (Levophed) RN/P

4 mg/250cc D5W

8 mg/250cc D5W

mcg/MIN

0.5 30 mcg/MIN

Mix in D5W if possible

Octreotide(Sandastatin)- P

500mcg/100cc

mcg/HOUR

25-50 mcg/HOUR

For variceal bleeding

Phenylephrine (Neosynephrine) RN/P

10 mg/250cc

20 mg/250cc

mcg/MIN

10-180 mcg/MIN

 

Primacor see Milronone

 

 

 

 

Procainamide(Pronestyl) P

2 grams/500cc

mg/MIN

1.0-4 mg/MIN

15-60cc/HOUR

Bolus = load 15-17 mg/kg over at least 30 minutes. Monitor Proc/NAPA levels and QT

Pronestyl see Procainamide

 

 

 

 

Propofol - B

200 mg/20ml

500mg/50ml

mcg/kg/MIN

5-50 mcg/kg/MIN

Change tubing every 12 hours and

Document on MAR

Thiopental - P

2000mg/500cc

mg/kg/HOUR

6-12mg/kg/HOUR for burst suppression

Burst suppression should be verified by BIS/EEG

Urokinase - P

250,000units/250ccNS

units/HOUR

60,000-100,000units/HOUR

 

Vasopressin - RN/P

100 units/500cc

20units/100cc

units/MIN

SEPSIS= up to 0.04 units/MIN

For pulseless VT/VF 40units IVPush

Versed see Midazolam

 

 

 

 

Xigris see Drotrecogin

 

 

 

 

 

** How prepared: B = premixed bag in pyxis RN = RN prepares drip P = Pharmacy prepares drip